Trial Terms Glossary


A type of clinical trial in which the participant and research team does not know if the participant is receiving the actual intervention versus a placebo. Blinding is used to remove any bias that can be caused intentionally or unintentionally.

Control Group

The group of participants that receive standard of care treatment or placebo. The control group may also be comprised of healthy volunteers.

Expanded Access

A potential pathway for a participant with an immediately life-threatening condition or serious disease to gain access to an investigational intervention when there are no other satisfactory options available.

Discussion Guide for Patients

We appreciate you taking the time to think about joining a clinical trial. We understand that this may be a difficult and emotional time for you, filled with a lot of information.

It is important to know that taking part in clinical trials is always completely voluntary. Research teams aim to update participants regularly, but you may still have questions. To help you guide these conversations with your research team, we have outlined some questions below that may be helpful for you to ask your study doctor and study coordinator. If you have any concerns with your safety, please immediately contact your study doctor and research team.

  • How might this effect my daily life?

  • Will I still be able to take part in activities that are important to me?

  • How do I prepare for each visit?

  • What kinds of test and experimental treatments are involved?

  • What precautions should I take in order to be able to complete study procedures and keep myself safe?

  • Who will be in charge of my care?

Financial Considerations

Due to the wide variety of interventions and conditions, all trials have different timelines. Before enrolling, the research team will outline the specific amount of time you will be participating. It could be only a few months or a few years, depending on the condition, intervention duration, and study requirements.

In general, trial participants do not pay extra out-of-pocket costs for an intervention in a clinical trial. However, there are still routine patient care costs and coverage varies between insurance plans. Some participants may be responsible for copays and payments toward a deductible. Some trials may or may not cover expenses such as travel, transportation, parking, or meals. You will learn more about these factors during pre-trial screening.

For clinical trial side effects or product inquiry reporting, please contact and talk with your study doctor or study coordinator to follow the reporting requirements and timelines specified in the applicable clinical trial protocol.

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